Institution: North Carolina State University

Institution’s URL: http://www.ncsu.edu/

Availability: Jan 2010

Salary: commensurate

Location: Raleigh, NC

Contact: gavin_williams@ncsu.edu

Synopsis:
Position #07-48-0914
The Department of Chemistry at North Carolina State University invites outstanding applications for a full time, 12-month (with a possibility of renewal dependent on satisfactory performance and continuation of funding) position of a Postdoctoral Research Associate, under the direction of Dr. Gavin Williams. You will be involved in projects involving the directed evolution of enzyme function, particularly those related to the biosynthesis of natural products and other small drug-like molecules. Our laboratory workspace if fully-equipped with molecular biology and protein production instrumentation and is newly-renovated. We also have access to robotic colony pickers and liquid handling machines. To be considered, applicants must have a Ph.D. in a bio-organic or related discipline. Experience with modern molecular biology techniques and organic synthesis is required, while expertise in directed evolution/natural product biosynthesis is preferred. The ideal candidate will be highly motivated, ambitious, and enthusiastic about working in the laboratory with scientists at all levels of training. Compensation is commensurate with experience.
Founded in 1887, North Carolina State University is the largest university in the State, with almost 32,000 students and 8,000 faculty and staff. NC State consistently ranks nationally among the top public universities and best higher-education values. For more information about NC State visit http://www.ncsu.edu.
Applicants should visit the job posting website at: https://jobs.ncsu.edu and search for position 07-48-0914 to submit an on-line application, detailed cover letter and Curriculum Vitae. Candidates should request that two references upload their reference letters directly into the NCSU HR Employment System. The position will remain open until a suitable candidate is found. Informal inquiries are encouraged and should be directed to Gavin_Williams@ncsu.edu.
North Carolina State University is an Equal Opportunity/Affirmative Action Employer. In addition, NC State University welcomes all persons without regard to sexual orientation.

A post-doctoral position is available to study enzymes of the pyrrolobenzodiazepines biosynthetic pathways. A strong background in protein biochemistry/enzymology with related publication history is required. Excellent communication skills and independence are essential. He/she must have a recent Ph.D. in chemistry/biochemistry or closely related field. A competitive salary is offered commensurate with qualifications and experience. Send curriculum vitae and names of three references to: Dr. Barbara Gerratana, Dept. of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 or to bgerrata@umd.edu. “EOE/AA”

Institution: University of Missouri-Kansas City

Institution’s URL: http://sbs.umkc.edu
Availability: October 2008

Salary: commensurate with applicable experience

Location: Kansas City, Missouri

Contact: miziorkoh@umkc.edu

Synopsis:
A position is available for a Ph.D. scientist (biochemistry, chemistry, structural biology, or medicinal chemistry background) to investigate enzymes of mevalonate metabolism/isoprenoid biosynthesis. Recombinant forms of these enzymes from animals and human pathogens (protozoa; bacteria) are available in our lab. Additionally, tight binding inhibitors (metabolite analogs) are available to support these studies. Several drug-like compounds have been implicated as potential inhibitors of these enzymes and these will also be evaluated to determine specificity and potency. Appropriate compounds will support collaborative structural work on enzyme-inhibitor complexes, leading to expanded structure/function studies.

Chemical synthesis of enzyme substrates/inhibitors as well as expression/isolation of recombinant proteins will be required for pursuit of the project. Experience with structural biology or computational approaches to study enzyme-ligand complexes would be an advantage for the candidate. Other requirements include the ability to pursue a project with some independence and a record of publications from previous research.

The laboratory is located in an attractive urban university campus, adjacent to pleasant residential areas as well as many venues for cultural and social activities. Position appointments include a generous fringe benefit package. Salary will be commensurate with appropriate experience. Interested candidates should forward a CV and contact information for professional references to:

Dr. Henry Miziorko
Marion-Merrell-Dow Professor
Molecular Biology & Biochemistry
University of Missouri-Kansas City
5007 Rockhill Road
Kansas City, MO 64110
miziorkoh@umkc.edu

Institution: Wayne State University

Institution’s URL: http://cphs.wayne.edu/psc/index.php

Availability: October 22, 2008

Salary: commensurate

Location: Detroit Michigan

Contact:sfirestine@wayne.edu

Synopsis:
The Department of Pharmaceutical Sciences in the Eugene Applebaum College of Pharmacy and Health Sciences is seeking postdoctoral candidates to immediately fill two openings. Candidates must have a recent Ph.D. in chemistry/biochemistry or a related field (medicinal chemistry, biochemistry, or chemical biology), possess good synthetic and biochemical skills and have a demonstrated record of quality publications. The candidates will work in the laboratory of Dr. Steven M. Firestine on a recently funded NIH project aimed at developing inhibitors of a critical protein-protein interaction involved in cytomegalovirus DNA replication. The ideal candidate will have excellent communication skills and be capable of operating independently. A competitive salary is offered commensurate with qualifications and experience. Send curriculum vitae and names of three references to: Dr. Steven Firestine, Dept. of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48201 or to sfirestine@wayne.edu.

Institution: Miziorko Lab; University of Missouri-Kansas City

Institution’s URL: http://sbs.umkc.edu
Availability: November 2008

Salary: commensurate with applicable experience

Location: Kansas City, Missouri

Contact: miziorkoh@umkc.edu

Synopsis:
A postdoctoral position is available (biochemistry, chemistry, structural biology, or medicinal chemistry background) to investigate enzymes of mevalonate metabolism/isoprenoid biosynthesis. Recombinant enzymes from animals and human pathogens (protozoa; bacteria) are available. Additionally, tight binding inhibitors (metabolite analogs) are available. Drug-like compounds will also be evaluated to determine specificity and potency. Appropriate compounds will support collaborative structural work on enzyme-inhibitor complexes, leading to expanded structure/function studies.

Chemical synthesis of enzyme substrates/inhibitors as well as expression/isolation of recombinant proteins will be required. Experience with structural biology or computational approaches to study enzyme-ligand complexes would be an advantage for the candidate.

Institution: University of Louisville Department of Chemistry

Institution’s URL: http://louisville.edu/~egmuel01

Availability: immediately

Salary: NIH fellowship rates (based on experience)

Location: Louisville, Kentucky

Contact: eugene.mueller@louisville.edu or (502) 852-5811

Synopsis:
Postdoctoral positions in the laboratory of Prof. Eugene Mueller are available immediately to investigate the mechanisms and ramifications of RNA modification and sulfur transfer. Requires a Ph.D. or equivalent degree in chemistry, biochemistry, biophysics or a related field.